ArtNr |
BOS-A06231 |
Hersteller |
Boster
|
Menge |
0.1mg |
Format |
Liquid |
Applikationen |
WB, IF, ELISA |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
Alias |
SPG15, FYVE-CENT, KIAA0321, Zinc finger FYVE domain-containing protein 26, FYVE domain-containing centrosomal protein |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies |
Manufacturers Research Category |
Apoptosis |
Short Description |
Boster Bio Anti-SPG15 ZFYVE26 Antibody (Catalog # A06231). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat. |
Description |
Boster Bio Anti-SPG15 ZFYVE26 Antibody (Catalog # A06231). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat. |
Background |
Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders. Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. SPG15 is the second gene known to be responsible for ARHSP-TCC in the Italian population. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. SPG15 encodes a protein containing a FYVE zinc finger binding domain which is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. SPG15 mRNA is widely distributed in human tissues, as well as in rat embryos, suggesting a possible role for this protein during embryonic development. SPG15 co-localizes partially with endoplasmic reticulum and endosome markers, suggesting a role in intracellular trafficking. |
Gene Name |
ZFYVE26 |
Clonality |
Polyclonal |
Concentration |
1 mg/mL |
Contents |
SPG15 Antibody is supplied in PBS containing 0.02% sodium azide. |
Predicted Reactivity |
Bovine |
Application Details |
SPG15 antibody can be used for detection of SPG15 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL. Antibody validated: Western Blot in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher. |
Immunogen |
SPG15 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human SPG15. The immunogen is located within amino acids 1710 - 1760 of SPG15. |
Cross-reactivity |
Multiple isoforms of SPG15 are known to exist. |
Purification |
SPG15 Antibody is affinity chromatography purified via peptide column. |
Storage |
SPG15 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Gene Full Name |
Zinc finger, FYVE domain containing 26 |
Molecular Weight |
284576 MW |
Protein Function |
Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. |
Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
Tissue Specificity |
Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord. |
Protein Name |
Zinc finger, FYVE domain containing 26 |
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