Anti-JMJD1A KDM3A Antibody

Primary Antibodies

Boster Bio Anti-JMJD1A KDM3A Antibody (Catalog # A03994-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Rat.

The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. JMJD1A is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of STAT3, a protein that has been found to be important in the maintenance of mouse embryonic stem (mES) cells, and decreased JMJD1A expression correlated with the differentiation of cultured mES cells following the removal of the cytokine LIF. These findings suggest that JMJD1A might be a critical signaling molecule underlying the maintenance of pluripotency in embryonic stem cells. At least two isoforms of JMJD1A are known to exist.

Polyclonal

JMJD1A Antibody is supplied in PBS containing 0.02% sodium azide.

WB: 1-2 μg/mL; IHC: 5 μg/mL; IF: 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples; Immunofluorescence in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

This antibody will not cross-react with JMJD1B or JMJD1C.

JMJD1A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

147341 MW

Cytoplasm. Nucleus
. Nuclear in round spermatids. When spermatids
start to elongate, localizes to the cytoplasm where it forms
distinct foci which disappear in mature spermatozoa (By
similarity)..