Anti-IRGM Antibody

Primary Antibodies

Boster Bio Anti-IRGM Antibody (Catalog # A03614). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease. IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa that also includes IRGM2 and IRGM3; this antibody may also recognize these proteins.

Polyclonal

IRGM Antibody is supplied in PBS containing 0.02% sodium azide.

IRGM antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of the human IRGM. The immunogen is located within amino acids 30 - 80 of IRGM.

IRGM antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

20142 MW

Golgi apparatus membrane. Cell
membrane. Cytoplasmic vesicle, phagosome membrane
. Cytoplasmic vesicle, autophagosome membrane
. Cell projection, phagocytic cup.
Behaves like an integral membrane protein. Recruited to the
plasma membrane around forming phagocytic cups, it remains
associated with maturing autophagosomes. Preferentially associated
with cis- and medial-Golgi..

Immunity-related GTPase family, M