Anti-LRRC8A Antibody

Primary Antibodies

Boster Bio Anti-LRRC8A Antibody (Catalog # A03517). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

The leucine rich repeat containing 8 family member A protein (LRRC8A) belongs the LRRC8 family of proteins within the LRR superfamily of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions (1, 2). LRRC8A is a four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation (1). LRRC8A has also been shown to be an essential component of the volume-regulated anion channel VRAC (3).

Polyclonal

LRRC8A antibody is supplied in PBS containing 0.02% sodium azide.

LRRC8A antibody was raised against a 15 amino acid peptide near the amino terminus of human LRRC8A. The immunogen is located within amino acids 60 - 110 of LRRC8A.

LRRC8A antibody is affinity chromatography purified via peptide column.

Leucine rich repeat containing 8 family, member A

Essential component of the volume-regulated anion
channel (VRAC, also named VSOAC channel), an anion channel
required to maintain a constant cell volume in response to
extracellular or intracellular osmotic changes (PubMed:24725410,
PubMed:24790029, PubMed:26530471, PubMed:26824658,
PubMed:28193731, PubMed:29769723). The VRAC channel conducts
iodide better than chloride and can also conduct organic osmolytes
like taurine (PubMed:24725410, PubMed:24790029, PubMed:26530471,
PubMed:26824658, PubMed:28193731). Mediates efflux of amino acids,
such as aspartate and glutamate, in response to osmotic stress
(PubMed:28193731). LRRC8A and LRRC8D are required for the uptake
of the drug cisplatin (PubMed:26530471). Required for in vivo
channel activity, together with at least one other family member
(LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend
on the precise subunit composition (PubMed:24790029,
PubMed:26824658, PubMed:28193731). Can form functional channels by
itself (in vitro) (PubMed:26824658). Involved in B-cell
development: required for the pro-B cell to pre-B cell transition
(PubMed:14660746). Also required for T-cell development (By
similarity).

Expressed in brain, kidney, ovary, lung,
liver, heart, and fetal brain and liver. Found at high levels in
bone marrow; lower levels are detected in peripheral blood cells.
Expressed on T-cells as well as on B-lineage cells.