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Anti-beta-Actin ACTB Antibody

Anti-beta-Actin ACTB Antibody

ArtNr	BOS-A01263-2
Hersteller	Boster
Menge	0.1mg
Format	Liquid
Applikationen	WB, IF, IHC, ELISA
Specific against	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
Alias	Beta actin, b actin
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Manufacturers Product Category	Primary Antibodies
Manufacturers Research Category	Homeostasis
Short Description	Boster Bio Anti-beta-Actin ACTB Antibody (Catalog # A01263-2). Tested in ELISA, WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-beta-Actin ACTB Antibody (Catalog # A01263-2). Tested in ELISA, WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
Background	Actins are highly conserved proteins that are involved in cell motility, structure and integrity, processes that are crucial for tissue development and the development of organism. The actin cytoskeleton is one of the principal drivers of cell motility and is capable of responding to complex signaling cascades. Recent evidence suggests that it may play key roles in regulating apoptosis and aging. Beta actin is one of six different actin isoforms which have been identified. Like GAPDH, beta-Actin is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.
Gene Name	ACTB
Clonality	Polyclonal
Concentration	1 mg/mL
Contents	beta-Actin Antibody is supplied in PBS containing 0.02% sodium azide.
Application Details	b-actin antibody can be used for the detection of b-actin by Western blot at 0.5 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 1 μg/mL. For immunofluorescence start at 2 μg/mL. Antibody validated: Western Blot in human and mouse samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Immunogen	b-actin antibody was raised against a 16 amino acid synthetic peptide from near the amino-terminus of human b-actin.
Purification	beta-Actin Antibody is affinity chromatography purified via peptide column.
Storage	beta-Actin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Gene Full Name	Actin, beta
Molecular Weight	41737 MW
Protein Function	Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:29581253). Actin exists in both monomeric (G- actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947).
Subcellular Localization	Cytoplasm, cytoskeleton
Tissue Specificity	Widely expressed, with the highest expression in lung, spleen and thymus.
Protein Name	Actin, beta

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Menge: 0.1mg

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Lieferung vsl. bis 30.08.2024

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