ArtNr |
BOS-A00993-1-10ug |
Hersteller |
Boster
|
Menge |
10ug |
Format |
Lyophilized |
Applikationen |
WB |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
Alias |
Urokinase plasminogen activator surface receptor;U-PAR;uPAR;Monocyte activation antigen Mo3;CD87;PLAUR;MO3, UPAR; |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies, Rabbit Polyclonal Antibodies |
Manufacturers Research Category |
Cancer, Cardiovascular, Cell Type Markers, Extracellular Matrix, Immunology, Invasion/Microenvironment, Receptors, Tumor Biomarkers |
Short Description |
Boster Bio Anti-uPA Receptor/PLAUR Antibody Picoband™ catalog # A00993-1. Tested in WB applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-uPA Receptor/PLAUR Antibody Picoband™ catalog # A00993-1. Tested in WB applications. This antibody reacts with Human. |
Background |
PLAUR (PLASMINOGEN ACTIVATOR RECEPTOR, UROKINASE-TYPE), also known as UPAR or CD87, is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol (GPI) anchor. PLAUR consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family. PLAUR is originally identified as a saturable binding site for urokinase on the cell surface. And the gene plays an important role in many normal as well as pathologic processes. The PLAUR gene is localized to 19q13.31. PLAUR is a part of the plasminogen activation system, which in the healthy body is involved in tissue reorganization events such as mammary gland involution and wound healing. PLAUR binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane. Thus it seems to be an important player in the regulation of this process. In human coronary artery vascular smooth muscle cells, UPA stimulates cell migration via a UPAR signaling complex containing TYK2 and phosphatidylinositol 3-kinase. |
Gene Name |
PLAUR |
Application Details |
Western blot, 0.1-0.5μg/ml, Human |
Application Notes |
Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. |
Clonality |
Polyclonal |
Concentration |
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml. |
Contents |
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
Immunogen |
E.coli-derived human PLAUR recombinant protein (Position: E230-S286). Human PLAUR shares 63.2% amino acid (aa) sequence identity with both mouse and rat PLAUR. |
Purification |
Immunogen affinity purified. |
Cross-reactivity |
No cross-reactivity with other proteins. |
Storage |
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles. |
Reconstitution |
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Gene Full Name |
Urokinase plasminogen activator surface receptor |
Molecular Weight |
36978 MW |
Protein Function |
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. |
Subcellular Localization |
Cell membrane. Cell projection, invadopodium membrane. Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.. |
Tissue Specificity |
Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain. |
Protein Name |
Urokinase plasminogen activator surface receptor(U-PAR/uPAR) |
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