Anti-Angiogenin ANG Antibody

Primary Antibodies

Boster Bio Anti-Angiogenin ANG Antibody (Catalog # A00146-1). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Angiogenin (ANG or ANG I) is important for the process of neovascularization and formation of new blood vessels. ANG is similar to pancreatic ribonuclease A and functions as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. It interacts with endothelial cell-surface actin and may cause changes in the cell cytoskeleton. ANG is thought to be involved in the development of solid tumors and its antagonists are capable of inhibiting tumor growth. Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9). Angiogenin is a genetic link between ALS and PD.

Polyclonal

ANG Antibody is supplied in PBS containing 0.02% sodium azide.

ANG antibody can be used for detection of ANG by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Two alternatively spliced transcript variants have been observed.

ANG antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

16550 MW

Cytoplasmic vesicle, secretory vesicle lumen

Angiogenin, ribonuclease, RNase A family, 5