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Anti-Angiogenin ANG Antibody

Anti-Angiogenin ANG Antibody

ArtNr	BOS-A00146-1
Hersteller	Boster
Menge	0.1 mg
Format	Liquid
Applikationen	WB, IF, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Alias	ALS9, RAA1, HEL168, RNASE4, RNASE5, Angiogenin, Ribonuclease 5, RNase 5
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	ANG antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Observed Molecular Weight	16550 MW
Clonality	Polyclonal
Application Details	ANG antibody can be used for detection of ANG by Western blot at 1 - 2 ?g/mL. For immunofluorescence start at 20 ?g/mL. Antibody validated: Western Blot in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Manufacturer - Gene Name	ANG
Gene Full Name	Angiogenin, ribonuclease, RNase A family, 5
Background	Angiogenin (ANG or ANG I) is important for the process of neovascularization and formation of new blood vessels. ANG is similar to pancreatic ribonuclease A and functions as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. It interacts with endothelial cell-surface actin and may cause changes in the cell cytoskeleton. ANG is thought to be involved in the development of solid tumors and its antagonists are capable of inhibiting tumor growth. Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9). Angiogenin is a genetic link between ALS and PD.
Immunogen	ANG antibody was raised against a 15 amino acid synthetic peptide near the center of human ANG. The immunogen is located within amino acids 70 - 120 of ANG.
Contents	ANG Antibody is supplied in PBS containing 0.02% sodium azide.
Purification	ANG Antibody is affinity chromatography purified via peptide column.
Concentration	1 mg/mL
Manufacturer - Research Category	Cancer, Cell Cycle
Protein Name	Angiogenin, ribonuclease, RNase A family, 5
Protein Function	Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Subcellular Localization	Cytoplasmic vesicle, secretory vesicle lumen
Short Description	Boster Bio Anti-Angiogenin ANG Antibody (Catalog # A00146-1). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-Angiogenin ANG Antibody (Catalog # A00146-1). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.
Predicted Reactivity	Horse

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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BOS-A00146-1-datasheet.pdf

BOS-A00146-1-safety-datasheet.pdf