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Anti-APC Antibody

Anti-APC Antibody

ArtNr	BOS-A00008
Hersteller	Boster
Menge	100ul
Format	Liquid
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
Alias	Adenomatous polyposis coli protein;Protein APC;Deleted in polyposis 2.5;APC;DP2.5;
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Manufacturers Product Category	Primary Antibodies
Short Description	Boster Bio Anti-APC Antibody catalog # A00008. Tested in ELISA, IF, IHC-P, WB applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-APC Antibody catalog # A00008. Tested in ELISA, IF, IHC-P, WB applications. This antibody reacts with Human, Mouse, Rat.
Gene Name	APC
Clonality	Polyclonal
Concentration	1 mg/ml
Contents	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Application Details	WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:40000
Immunogen	Synthesized peptide derived from the C-terminal region of human APC. at AA range: 2770-2850
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
Storage	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Gene Full Name	Adenomatous polyposis coli protein
Molecular Weight	311646 MW
Protein Function	Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization..
Subcellular Localization	Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm. Cell membrane. Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment (PubMed:19151759). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854)..
Tissue Specificity	Expressed in a variety of tissues.

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Menge: 100ul

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Lieferung vsl. bis 30.08.2024

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