Background |
LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. |
Manufacturers Research Area |
Cancer, Signal transduction, Endocrine metabolism, Lipid metabolism, Lipases, Endocrine and metabolic diseases, Obesity, Neuroscience, Neurodegenerative diseases, Stem cells, Mesenchymal stem cells, Cardiovascular, Lipids |