PPP3CC Antibody (C-term) Blocking Peptide

Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha, calcineurin A-beta, and calcineurin A-gamma, have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).

5533

Synthetic peptide

The synthetic peptide sequence used to generate the antibody AP8465b was selected from the C-term region of human PPP3CC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.