Similar products |
PIK3CG, Phosphatidylinositol 4, 5-bisphosphate 3-kinase catalytic subunit gamma isoform, 5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, Phosphoinositide-3-kinase catalytic gamma polypeptide, PI3Kgamma, PI3-kinase subunit gamma, PI3K-gamma, PtdIns-3-kinase subunit gamma, PtdIns-3-kinase subunit p110-gamma, p110gamma, Serine/threonine protein kinase PIK3CG, p120-PI3K |
Bio Background |
PI3KCG belongs to the pi3/pi4-kinase family of proteins. It is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene for this protein is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. |
Bio References |
Andreozzi, F., et al., Endocrinology 145(6):2845-2857 (2004).Reddy, S.A., et al., Biochem. Biophys. Res. Commun. 316(4):1022-1028 (2004).Osaki, M., et al., J. Cancer Res. Clin. Oncol. 130(1):8-14 (2004).Khan, N.A., et al., J. Neurovirol. 9(6):584-593 (2003).Theberge, J.F., et al., Arch. Biochem. Biophys. 420(1):9-17 (2003). |