Bio Background |
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). |
Bio References |
Inoue, H., et al. Biosci. Biotechnol. Biochem. 73(11):2488-2493(2009)Di Nardo, A., et al. J. Neurosci. 29(18):5926-5937(2009)Chen, P., et al. Exp. Mol. Pathol. 86(2):101-107(2009)Momose, S., et al. Biochem. Biophys. Res. Commun. 356(3):693-698(2007)Goncharova, E., et al. J. Cell Biol. 167(6):1171-1182(2004) |