Similar products |
p21, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1, Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6 |
Bio Background |
p21 is a potent cyclin-dependent kinase inhibitor. It binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this protein is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. p21 can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. It was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. |
Bio References |
Scott, S.A., et al., Leuk. Res. 28(12):1293-1301 (2004).Amini, S., et al., J. Biol. Chem. 279(44):46046-46056 (2004).Chen, T., et al., Cancer Res. 64(20):7412-7419 (2004).Sieburg, M., et al., J. Virol. 78(19):10399-10409 (2004).Giraud, S., et al., Oncogene 23(44):7391-7398 (2004). |