ArtNr |
ABC-BP2845c |
Hersteller |
Abcepta
|
Menge |
500 ug |
Kategorie |
|
Typ |
Peptides |
Format |
Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Similar products |
SHIP1, INPP5D, Phosphatidylinositol 3, SHIP-1, 5-trisphosphate 5-phosphatase 1, hp51CN, Inositol polyphosphate-5-phosphatase of 145 kDa, p150Ship, SH2 domain-containing inositol phosphatase 1, SIP-145, SHIP, SHIP, SH2 domain-containing inositol 5'-phosphatase 1 |
Lieferbar |
|
Primary Accession |
Q92835 |
Bio Background |
INPP5D is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and it is a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3, 4, 5)-trisphosphate and inositol-1, 3, 4, 5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. |
Bio References |
Gilby, D.C., Leukemia 21 (11), 2390-2393 (2007)Gloire, G., Biochem. Soc. Trans. 35 (PT 2), 277-280 (2007)Vaillancourt, M., Cell. Signal. 18 (11), 2022-2032 (2006) |
Gene ID |
3635 |
Gene Name |
INPP5D |
Subtitle |
Synthetic peptide |
Target/Specificity |
The synthetic peptide sequence used to generate the antibody AP2845c was selected from the Center region of human INPP5D. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
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