ArtNr |
ABC-BP21435b |
Hersteller |
Abcepta
|
Menge |
500 ug |
Kategorie |
|
Typ |
Peptides |
Format |
Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Similar products |
CREB3, LZIP, Cyclic AMP-responsive element-binding protein 3, Luman, Transcription factor LZIP-alpha, Processed cyclic AMP-responsive element-binding protein 3, cAMP-responsive element-binding protein 3, Leucine zipper protein, Transcriptionally active form, CREB-3, N-terminal Luman |
Lieferbar |
|
Primary Accession |
O43889 |
Bio Background |
Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation level of histone H4. Isoform 3 does not promote the chemotactic activity of leukocyte cells. |
Bio References |
Lu R., et al.Mol. Cell. Biol. 17:5117-5126(1997).Freiman R.N., et al.Genes Dev. 11:3122-3127(1997).Jin D.-Y., et al.EMBO J. 19:729-740(2000).Kang H., et al.Mol. Endocrinol. 23:1746-1757(2009).Hayashi M., et al.Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases. |
Gene ID |
10488 |
Gene Name |
CREB3 |
Subtitle |
Synthetic peptide |
Target/Specificity |
The synthetic peptide sequence is selected from aa 311-324 of HUMAN CREB3 |
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