VEGFD (VEGF4) Antibody Blocking peptide

Vascular endothelial growth factors (VEGFs) are a family of secreted glycoproteins which act as mitogens primarily for vascular endothelial cells. VEGF-C (VEGF3) and VEGF-D (VEGF4) are recently identified members which share the conserved VEGF Homology Domain. They both have long N- and C-terminal propeptide extensions, and undergo proteolytic processing. Both VEGF-C and VEGF-D are widely expressed with highest expression in lymphnodes. The receptors VEGFR2 and VEGFR3 are expressed in vascular endothelial cells and lymphatic endothelial cells. VEGF-C and VEGFR3 are usually co-expressed at growing lymphatic endothelial cells. The VEGF-C/VEGFR3 signaling pathway has been shown to be crucial for lymphatic development. Recently increased expression of VEGF-C has been linked to a variety of human tumors and correlates with increased lymphatic density and lymph node metastasis.

2277

Synthetic peptide