Vergleich

BMPR1A Antibody (N-term K36) Blocking Peptide

ArtNr ABC-BP2004c
Hersteller Abcepta
Menge 500 ug
Kategorie
Typ Peptides
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Specific against other
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Similar products BMPR1A, Bone morphogenetic protein receptor type-1A, Activin receptor-like kinase 3, Serine/threonine-protein kinase receptor R5, ACVRLK3, ALK3, CD292, SKR5, ALK-3, BMPR-1A, BMP type-1A receptor
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Primary Accession
P36894
Bio Background
The bone morphogenetic protein (BMP) receptors belong to a family of transmembrane serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. Both activins and TGF-beta transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMP receptors are highly expressed in bone, skeletal muscle, heart and liver tissue. BMPRs play a crucial role during development as mutations or deletions to the BMPR genes can cause juvenile polyposis, disrupt normal dorsal/ventral patterning during limb development, and may be a factor in the progession of Cowden-like syndrome. Germline mutations in the BMPR2 gene encoding bone morphogenetic protein (BMP) type II receptor (BMPR-II) have been reported in patients with primary pulmonary hypertension (PPH).
Bio References
Zhou, X.-P., et al., Am. J. Hum. Genet. 69(4):704-711 (2001).Howe, J.R., et al., Nat. Genet. 28(2):184-187 (2001).ten Dijke, P., et al., Oncogene 8(10):2879-2887 (1993).
Gene ID
657
Gene Name
BMPR1A
Subtitle
Synthetic peptide
Other Accession
NP_004320
Target/Specificity
The synthetic peptide sequence used to generate the antibody AP2004c was selected from the N-term region of human BMPR1A . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 500 ug
Lieferbar: In stock
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