Bio Background |
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. |
Bio References |
Bauer, A., et al., EMBO J. 19(22):6121-6130 (2000).Parfait, B., et al., Ann. Genet. 43(2):69-74 (2000).Wood, M.A., et al., Mol. Cell 5(2):321-330 (2000).Salzer, U., et al., Biochim. Biophys. Acta 1446(3):365-370 (1999).Kanemaki, M., et al., J. Biol. Chem. 274(32):22437-22444 (1999). |