PTEN Antibody (Center S294) Blocking Peptide

This gene was identified as a tumor suppressor that ismutated in a large number of cancers at high frequency. The proteinencoded this gene is a phosphatidylinositol-3, 4, 5-trisphosphate3-phosphatase. It contains a tensin like domain as well as acatalytic domain similar to that of the dual specificity proteintyrosine phosphatases. Unlike most of the protein tyrosinephosphatases, this protein preferentially dephosphorylatesphosphoinositide substrates. It negatively regulates intracellularlevels of phosphatidylinositol-3, 4, 5-trisphosphate in cells andfunctions as a tumor suppressor by negatively regulating AKT/PKBsignaling pathway.

5728

Synthetic peptide