Similar products |
ACCN3, ASIC3, SLNAC1, TNAC1, Acid-sensing ion channel 3, Amiloride-sensitive cation channel 3, Neuronal amiloride-sensitive cation channel 3, Testis sodium channel 1, hASIC3, hTNaC1 |
Bio Background |
This gene encodes a member of the degenerin/epithelialsodium channel (DEG/ENaC) superfamily. The members of this familyare amiloride-sensitive sodium channels that contain intracellularN and C termini, two hydrophobic transmembrane regions, and a largeextracellular loop, which has many cysteine residues with conservedspacing. The member encoded by this gene is an acid sensor and mayplay an important role in the detection of lasting pH changes. Inaddition, a heteromeric association between this member and ACCN1has been observed as proton-gated channels sensitive to gadolinium.Alternative splicing of this gene generates three transcriptvariants encoding distinct isoforms. |
Bio References |
Borzan, J., et al. Anesthesiology 113(3):647-654(2010)Wu, S., et al. Clin. Chim. Acta 411 (15-16), 1132-1136 (2010) :Ko, Y.L., et al. J. Hypertens. 26(11):2154-2160(2008)Su, X., et al. J. Biol. Chem. 281(48):36960-36968(2006)Jones, N.G., et al. J. Neurosci. 24(48):10974-10979(2004) |