Bio Background |
This gene is a member of the CLC family of voltage-gatedchloride channels. The encoded protein is predicted to have 12transmembrane domains, and requires a beta subunit called barttinto form a functional channel. It is thought to function in saltreabsorption in the kidney and potassium recycling in the innerear. The gene is highly similar to CLCNKB, which is located 10 kbdownstream from this gene. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq]. |
Bio References |
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Kramer, B.K., et al. Nat Clin Pract Nephrol 4(1):38-46(2008)Martinez, G.Q., et al. PLoS ONE 3 (7), E2746 (2008) :Sile, S., et al. Hum. Hered. 65(1):33-46(2008) |