Bio Background |
CDH12 is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. |
Bio References |
Shimoyama, Y., Biochem. J. 349 (PT 1), 159-167 (2000)Chalmers, I.J., Genomics 57 (1), 160-163 (1999)Kremmidiotis, G., Genomics 49 (3), 467-471 (1998)Selig, S., Proc. Natl. Acad. Sci. U.S.A. 94 (6), 2398-2403 (1997) |