Bio Background |
The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domainand a putative nuclear localization signal. The MDM4 putativenuclear localization signal, which all Mdm proteins contain, islocated in the C-terminal region of the protein. The mRNA isexpressed at a high level in thymus and at lower levels in allother tissues tested. MDM4 protein produced by in vitro translationinteracts with p53 via a binding domain located in the N-terminalregion of the MDM4 protein. MDM4 shows significant structuralsimilarity to p53-binding protein MDM2. Two transcript variants, one protein-coding and the other likely not to be protein-coding, have been found for this gene. |
Bio References |
Xu, N., et al. Biochem. Biophys. Res. Commun. 401(3):417-421(2010)Sarkari, F., et al. J. Mol. Biol. 402(5):825-837(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Fang, S., et al. PLoS ONE 5 (5), E10813 (2010) : |