Bio Background |
Histones play a critical role in transcriptionalregulation, cell cycle progression, and developmental events.Histone acetylation/deacetylation alters chromosome structure andaffects transcription factor access to DNA. The protein encoded bythis gene belongs to the histone deacetylase/acuc/apha family. Ithas histone deacetylase activity and represses transcription whentethered to a promoter. It may participate in the regulation oftranscription through its binding with the zinc-fingertranscription factor YY1. This protein can also down-regulate p53function and thus modulate cell growth and apoptosis. This gene isregarded as a potential tumor suppressor gene. [provided byRefSeq]. |
Bio References |
Minamiya, Y., et al. Tumour Biol. 31(5):533-539(2010)Kim, H.C., et al. Cell. Mol. Life Sci. 67(20):3499-3510(2010)Yang, Z., et al. Clin. Chem. Lab. Med. (2010) In press :Kim, T., et al. Psychiatry Res 178(2):266-269(2010)Adams, H., et al. Expert Opin. Ther. Targets 14(6):577-584(2010) |