Bio Background |
This gene is a member of the Antp homeobox family andencodes a protein with a homeobox DNA-binding domain. It isincluded in a cluster of homeobox B genes located on chromosome 17.The encoded protein functions as a sequence-specific transcriptionfactor that is involved in development, including that of lung andskin, and has been localized to both the nucleus and cytoplasm.Altered expression of this gene or a change in the subcellularlocalization of its protein is associated with some cases of acutemyeloid leukemia and colorectal cancer. |
Bio References |
Ferrai, C., et al. Mol. Biol. Cell 20(15):3543-3551(2009)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Chen, T., et al. Eur. J. Hum. Genet. 15(1):23-28(2007)Shen, W., et al. J. Biol. Chem. 279(38):39895-39904(2004) |