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GABA-B-R1, GABABR1, GPRC3A, GABBR1, Gb1, Gamma-aminobutyric acid type B receptor subunit 1, GABA-B receptor 1, GABA-BR1, Gb1 |
Bio Background |
Gamma-aminobutyric acid (GABA) is the main inhibitoryneurotransmitter in the mammalian central nervous system. GABAexerts its effects through ionotropic [GABA(A/C)] receptors, toproduce fast synaptic inhibition, and metabotropic [GABA(B)]receptors, to produce slow, prolonged inhibitory signals. TheGABA(B) receptor consists of a heterodimer of two related7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3within the HLA class I region close to the HLA-F gene.Susceptibility loci for multiple sclerosis, epilepsy, andschizophrenia have also been mapped in this region. Alternativesplicing of this gene generates multiple transcript variants. |
Bio References |
Cramer, N.P., et al. Adv. Pharmacol. 58, 397-426 (2010) :Gonzalez-Burgos, G. Adv. Pharmacol. 58, 175-204 (2010) :Tabata, T., et al. Adv. Pharmacol. 58, 149-173 (2010) :Padgett, C.L., et al. Adv. Pharmacol. 58, 123-147 (2010) :Terunuma, M., et al. Adv. Pharmacol. 58, 113-122 (2010) : |