GABBR1 Antibody (Center) Blocking peptide

Gamma-aminobutyric acid (GABA) is the main inhibitoryneurotransmitter in the mammalian central nervous system. GABAexerts its effects through ionotropic [GABA(A/C)] receptors, toproduce fast synaptic inhibition, and metabotropic [GABA(B)]receptors, to produce slow, prolonged inhibitory signals. TheGABA(B) receptor consists of a heterodimer of two related7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3within the HLA class I region close to the HLA-F gene.Susceptibility loci for multiple sclerosis, epilepsy, andschizophrenia have also been mapped in this region. Alternativesplicing of this gene generates multiple transcript variants.

2550

Synthetic peptide