Bio Background |
The 3', 5'-cyclic nucleotides cAMP and cGMP function assecond messengers in a wide variety of signal transductionpathways. 3', 5'-cyclic nucleotide phosphodiesterases (PDEs)catalyze the hydrolysis of cAMP and cGMP to the corresponding5'-monophosphates and provide a mechanism to downregulate cAMP andcGMP signaling. This gene encodes a cAMP-specificphosphodiesterase, a member of the cyclic nucleotidephosphodiesterase family. |
Bio References |
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kestenbaum, B., et al. J. Am. Soc. Nephrol. 21(7):1223-1232(2010)Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Ikeda, M., et al. Biol. Psychiatry 67(3):263-269(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) |