[Novoprotein] Recombinant Mouse/Rat Bone Morphogenetic Protein 7

Bone morphogenetic protein 7 (BMP-7) is a widely expressed TGF-ß superfamily member with important functions during embryogenesis, in the adult, & in disease. The growth factor domain of mouse BMP-7 shares 98% & 100% aa sequence identity with human & rat BMP-7, respectively. The BMP-7 propeptide is cleaved intracellularly but remains in association with the growth factor domain. BMP-7 is subsequently secreted as a tetramer that consists of two propeptides & two disulfide-linked growth factor domains. Mature BMP-7 can also form disulfide-linked heterodimers with BMP-2 or BMP-4, complexes that show increased potency & range of activity compared to BMP-7 homodimers. BMP-7 exerts its biological effects through the type 2 receptors Activin RIIA, Activin RIIB, & BMPR-II & the type 1 receptors Activin RIA, BMPR-IA, & BMPR-IB. BMP-7 plays a role in a variety of organ systems. It promotes new bone formation & nephron development, inhibits the branching of prostate epithelium, & antagonizes epithelial-mesenchymal transition (EMT). In pathological conditions, BMP-7 inhibits tumor growth & metastasis, ameliorates fibrotic damage in nephritis, & promotes neuroregeneration following brain ischemia.

Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

15.6kD

Ambient