ArtNr |
NKM-ATGP3612-50ug |
Hersteller |
NKMAX
|
Menge |
50ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Konjugat/Tag |
hIgG-His-Tag |
Purity |
> 90% by SDS - PAGE |
Sequence |
ADPPGWFLDS PDRPWNPPTF SPALLVVTEG DNATFTCSFS NTSESFVLNW YRMSPSNQTD KLAAFPEDRS QPGQDCRFRV TQLPNGRDFH MSVVRARRND SGTYLCGAIS LAPKAQIKES LRAELRVTER RAEVPTAHPS PSPRPAGQFQ TLVLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP R |
NCBI |
NP_005009 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Programmed cell death protein 1, PDCD1, CD279, hPD-1, hPD-l, hSLE1, PD-1, PD1, SLEB2 |
Lieferbar |
|
Antigen Species |
Human |
Applications info |
SDS-PAGE |
Concentration |
0.5mg/ml (determined by Absorbance at 280nm) |
Description |
PDCD1, also known as programmed cell death protein 1, is a type 1 transmembrane glycoprotein, and is an immune-receptor belonging to the CD28/CTLA4 family. This protein is expressed on the surface of activated T-cell, B-cell, macrophages, myeloid cells and subset of thymocytes. Also, it inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4 and IL-10. As a cell surface molecule, it regulates the adaptive immune response. Recombinant human PDCD1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
Domain |
21-170aa |
Endotoxin |
< 1.0 EU per 1ug of protein (determined by LAL method) |
Expression System |
Baculovirus |
Formulation |
Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
Gene Category |
Apoptosis |
General References |
Ishida Y., et al, (1992) EMBO J. 11:3887-3895. Lastwika KJ., et al, (2016) Cancer Res. 76:227-238. |
Molecular Weight |
44.0kDa (392aa) 40-57kDa (SDS-PAGE under reducing conditions.) |
Storage |
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
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