ArtNr |
NKM-ATGP1639-0.5mg |
Hersteller |
NKMAX
|
Menge |
0.5mg |
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Konjugat/Tag |
His-Tag |
Purity |
> 90% by SDS - PAGE |
Sequence |
MGSSHHHHHH SSGLVPRGSH MGSHMSAETA SGPTEDQVEI LEYNFNKVDK HPDSTTLCLI AAEAGLSEEE TQKWFKQRLA KWRRSEGLPS ECRSVTD |
NCBI |
NP_631957 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Homeodomain-only protein, CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO |
Lieferbar |
|
Antigen Species |
Human |
Applications info |
SDS-PAGE |
Concentration |
1 mg/ml (determined by Bradford assay) |
Description |
HOPX, also known as homeodomain-only protein, acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. This protein prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Recombinant human HOPX protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. |
Domain |
1-73aa |
Expression System |
E.coli |
Formulation |
Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol |
Gene Category |
Epigenomics (Transcription & Translation) |
General References |
Adu J., et al. (2002) Mech. Dev. 119:S43-S47 Lemaire F., et al. (2007) Br. J. Cancer. 91:258-261 |
Molecular Weight |
10.8 kDa (97aa), confirmed by MALDI-TOF |
Storage |
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
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