ArtNr |
NKM-ATGP1282-100ug |
Hersteller |
NKMAX
|
Menge |
100ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Konjugat/Tag |
His-Tag |
Purity |
> 95% by SDS - PAGE |
Sequence |
MGSSHHHHHH SSGLVPRGSH MAHAPARCPS ARGSGDGEMG KPRNVALITG ITGQDGSYLA EFLLEKGYEV HGIVRRSSSF NTGRIEHLYK NPQAHIEGNM KLHYGDLTDS TCLVKIINEV KPTEIYNLGA QSHVKISFDL AEYTADVDGV GTLRLLDAVK TCGLINSVKF YQASTSELYG KVQEIPQKET TPFYPRSPYG AAKLYAYWIV VNFREAYNLF AVNGILFNHE SP |
NCBI |
NP_001491 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
GDP-mannose 46 dehydratase, GDP-mannose 4,6 dehydratase, GMD, SDR3E1 |
Lieferbar |
|
Antigen Species |
Human |
Applications info |
SDS-PAGE |
Concentration |
0.5 mg/ml (determined by Bradford assay) |
Description |
GMDS, also known as SDR3E1, belongs to the GDP-mannose 4, 6-dehydratase family. This protein utilizes NADP as a cofactor to catalyze the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose. Mutations in the gene encoding GMDS are involved in resistance to TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) -induced apoptosis. Recombinant human GMDS protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. |
Domain |
1-372aa |
Expression System |
E.coli |
Formulation |
Liquid. 20mM Tris-HCl buffer (pH8.0) containing 30% glycerol, 0.1M NaCl, 1mM DTT, 0.1mM PMSF |
Gene Category |
Metabolism |
General References |
Ohyama C. et al. (1998) J Biol Chem. 273: 14582-14587. Moriwaki K. et al. (2009) Gastroenterology 137: 188-198. |
Molecular Weight |
44.1 kDa (392aa), confirmed by MALDI-TOF |
Storage |
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
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