ArtNr |
NKM-ATGP0487-0.5mg |
Hersteller |
NKMAX
|
Menge |
0.5mg |
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Konjugat/Tag |
His-Tag |
Purity |
> 90% by SDS - PAGE |
Sequence |
MGSSHHHHHH SSGLVPRGSH MHSLLPVDDA INGLSEEQRQ LRQTMAKFLQ EHLAPKAQEI DRSNEFKNLR EFWKQLGNLG VLGITAPVQY GGSGLGYLEH VLVMEEISRA SGAVGLSYGA HSNLCINQLV RNGNEAQKEK YLPKLISGEY IGALAMSEPN AGSDVVSMKL KAEKKGNHYI LNGNKFWITN GPDADVLIVY AKTDLAAVPA SRGITAFIVE KGMPGFSTSK KL |
NCBI |
NP_002216 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Isovaleryl-CoA dehydrogenase mitochondrial, ACAD2, Isovaleryl-CoA dehydrogenase, mitochondrial Isovaleryl CoA dehydrogenase, Isovaleryl CoA dehydrogenase, mitochondrial, isovaleryl Coenzyme A dehydrogenase. |
Lieferbar |
|
Antigen Species |
Human |
Applications info |
SDS-PAGE |
Concentration |
1 mg/ml (determined by Bradford assay) |
Description |
IVD (Isovaleryl Coenzyme A dehydrogenase) is a mitochondrial matrix enzyme that belongs to the acyl-CoA dehydrogenase family. IVD is a homotetrameric flavoenzyme which catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA. Defects of the IVD gene lead to ineffective isoforms that are the underlying cause of isovaleric acidemia. Recombinant human IVD protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. |
Domain |
33-426aa |
Expression System |
E.coli |
Formulation |
Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol |
Gene Category |
Redox Proteins |
General References |
Hodges PW., et al. (2009) Eur J Neurosci. 29(7):1490-500. Rohini R., et al. (2009) Eur J Med Chem. 44(8):3330-9. |
Molecular Weight |
45.3 kDa (415aa), confirmed by MALDI-TOF. |
Storage |
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
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