Vergleich

Human TDP1 antibody

ArtNr NKM-ATGA0157-100ul
Hersteller NKMAX
Menge 100ul
Kategorie
Typ Antibody Monoclonal
Clon AT1F2
Specific against other
Host Mouse
Isotype IgG2b kappa
Konjugat/Tag Unconjugated
NCBI NP_060789
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias tyrosyl-DNA phosphodiesterase 1, FLJ11090, SCAN1
Lieferbar
Antigen Species
Human
Applications info
ELISA, WB, FACS, ICC/IF
Clonality Mono VS Poly
Monoclonal
Concentration
1mg/ml
Description
Tyrosyl-DNA phosphodiesterase (TDP1) is a DNA repair enzyme that catalyzes the hydrolysis of a phophodiester bond between a tyrosine residue and a DNA 3' phosphate. This protein is a member of the phospholipase D (PLD) superfamily and contains two PLD phosphodiesterase domains. Mutations in TDP1 are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1) by interfering with DNA transcription or by inducting apoptosis in postmitotic neurons.
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol.
Gene Category
Cell Cycle
General References
Dexheimer TS, et al., (2008) Anticancer Agents Med Chem. 8(4):381-9
EI-Khamisy SF, Caldecott KW., (2006) Mutagenesis. 21(4):219-24
Immunogen
Recombinant human TDP1 (1-298aa) purified from E. coli
Reacts With
Human
Storage
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Usage
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1000 ca. 2000. Recommended starting dilution is 1:1000.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100ul
Lieferbar: In stock
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