ArtNr |
NKM-ACS0820-100ul |
Hersteller |
NKMAX
|
Menge |
100ul |
Kategorie |
|
Typ |
Antibody Monoclonal |
Clon |
2F1 |
Specific against |
other |
Host |
Mouse |
Isotype |
IgG2b kappa |
Konjugat/Tag |
Unconjugated |
NCBI |
NP_000091 |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
CystatinB, Cystatin B, CSTB, Stefin B, PME, CST6, CystatinB CHROW21, CPI B, CYTB, EPM1, Liver thiol proteinase inhibitor, STFB. |
Lieferbar |
|
Antigen Species |
Human |
Applications info |
ELISA, WB, ICC/IF |
Clonality Mono VS Poly |
Monoclonal |
Concentration |
1mg/ml |
Description |
CSTB, also known as Cystatin B is an anti-protease implicated in myoclonus epilepsy, a degenerative disease of the central nervous system. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. This protein is able to from a dimer stabilized by noncovalent forces and is thought to play a role in protecting against the proteases leaking from lysosomes in cells. CSTB is located in the lysosomes and the cytoplasm, but also in the nucleus. |
Formulation |
Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol. |
Gene Category |
Neuroscience |
General References |
Turk V, et al., (1991) FEBS Lett. 285(2):213-9 Jarvinen M, et al., (1988) Acta Histochem. 82(1):5-18 |
Immunogen |
Recombinant human CSTB (1-98aa) purified from E. coli |
Reacts With |
Human |
Storage |
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
Usage |
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1, 000ca. 2, 000. Recommended starting dilution is 1:1, 000. |
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