peramivir

Description: Peramivir (also known as BCX-1812, RWJ-270201, S-021812) is an antiviral agent peramivir which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM. Peramivir protects mice against severe disease outcomes following infection with highly pathogenic avian influenza and multi-dose treatment was efficacious in ferrets. Peramivir combined with Oseltamivir perform better than suboptimal doses of each compound alone to treat influenza infections in mice. Peramivir (30 mg/kg) is effective in promoting the survival of mice infected with systemically replicating H5N1 virus.

References: Virology. 2008 Apr 25; 374(1):198-209; Antiviral Res. 2010 Oct; 88(1):38-44; Antiviral Res. 2008 Nov; 80(2):150-7.

Related CAS #: 330600-85-6 (free) 1041434-82-5 (hydrate)