cct-241533-hcl

InvivoChem Cat #:V5293CAS #:1431697-96-9Purity >=98%

Description: CCT 241533 dihydrochloride is a novel, potent and selective CHK2 inhibitor with an IC50 of 3 nM and a Ki of 1.16 nM. It shows > 63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. CCT 241533 dihydrochloride inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells and blocks ionizing radiation-induced apoptosis of mouse thymocytes.

References: Cancer Res. 2011 Jan 15; 71(2):463-72.; J Med Chem. 2011 Jan 27; 54(2):580-90.

Related CAS: 1262849-73-9 (free Base) 1431697-96-9 (2HCl)

-20C for 3 years in powder form

Synonym: CCT241533; CCT-241533; CCT 241533; CCT-241533 HCl; CCT 241533 dihydrochloride
Chemical Name: (3R, 4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6, 7-dimethoxy-4-quinazolinyl]amino]-alpha, alpha-dimethyl-3-pyrrolidinemethanol dihydrochloride
InChi Key: VCFVLTMSBOZYOU-FXKISCCRSA-N
InChi Code: InChI=1S/C23H27FN4O4.2ClH/c1-23(2, 30)15-10-25-11-17(15)27-21-13-8-19(31-3)20(32-4)9-16(13)26-22(28-21)14-7-12(24)5-6-18(14)29; ; /h5-9, 15, 17, 25, 29-30H, 10-11H2, 1-4H3, (H, 26, 27, 28); 2*1H/t15-, 17-; ; /m1../s1
SMILES Code: OC(C)(C)[CH]1CNC[CH]1NC2=C3C=C(OC)C(OC)=CC3=NC(C4=CC(F)=CC=C4O)=N2.[H]Cl.[H]Cl