Description |
InvivoChem Cat #:V5267CAS #:1860875-51-9 Purity >=98%Description: CC-90009 is a novel and potent modulator of cereblon (CRBN), which is part of the cullin 4-RING E3 ubiquitin ligase complex (CRL4-CRBN E3 ubiquitin ligase; CUL4-CRBN E3 ubiquitin ligase), with potential immunomodulating and pro-apoptotic activities. Upon administration, CC-90009 specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex. This leads to the ubiquitination of certain substrate proteins and induces the proteasome-mediated degradation of certain transcription factors, including Ikaros (IKZF1) and Aiolos (IKZF3), which are transcriptional repressors in T-cells. This reduces the levels of these transcription factors, and modulates the activity of the immune system, which may include the activation of T-lymphocytes. In addition, this downregulates the expression of other proteins, including interferon regulatory factor 4 (IRF4) and c-myc, which plays a key role in the proliferation of certain cancer cell types. CRBN, the substrate recognition component of the E3 ubiquitin ligase complex, plays a key role in the ubiquitination of certain proteins.
References: https://www.cancer.gov/publications/dictionaries/cancer-drug/def/cereblon-modulator-cc-90009
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Name: CC-90009 CAS#: 1860875-51-9 Chemical Formula: C22H18ClF2N3O4 Exact Mass: 461.0954 Molecular Weight: 461.8498 Elemental Analysis: C, 57.21; H, 3.93; Cl, 7.68; F, 8.23; N, 9.10; O, 13.86 |
Technical Information |
Synonym: CC-90009; CC 90009; CC90009 Chemical Name: 2-(4-chlorophenyl)-N-((2-(2, 6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2, 2-difluoroacetamide InChi Key: PWBHUSLMHZLGRN-UHFFFAOYSA-N InChi Code: InChI=1S/C22H18ClF2N3O4/c23-15-4-2-14(3-5-15)22(24, 25)21(32)26-10-12-1-6-16-13(9-12)11-28(20(16)31)17-7-8-18(29)27-19(17)30/h1-6, 9, 17H, 7-8, 10-11H2, (H, 26, 32)(H, 27, 29, 30) SMILES Code: O=C(NCC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2)=O)C=C1)C(F)(C4=CC=C(Cl)C=C4)F |