Description |
InvivoChem Cat #:V5226CAS #:1815580-06-3Purity >=98%Description: SKLB-23bb (23bb) is a novel, potent, orally bioavailable and selective inhibitor for HDAC6 with an IC50 of 17 nM and shows 25-fold and 200-fold selectivity relative to HDAC1 (IC50=422 nM) and HDAC8 (IC50=3398 nM), respectively. SKLB-23bb also has microtubule-disrupting ability. In vitro, 23bb presented low nanomolar antiproliferative effects against panel of cancer cell lines. Western blot analysis further confirmed that 23bb increased acetylation level of alpha-tubulin in vitro. 23bb has a good pharmacokinetic profile with oral bioavailability of 47.0% in rats. In in vivo efficacy evaluations of colorectal HCT116, acute myelocytic leukemia MV4-11, and B cell lymphoma Romas xenografts, 23bb more effectively inhibited the tumor growth than SAHA even at a 4-fold reduced dose or ACY-1215 at the same dose. References: J Med Chem. 2016 Feb 25; 59(4):1455-70. |
![SKLB-23bb]()
|
Name: SKLB-23bb CAS#: 1815580-06-3 Chemical Formula: C21H24N4O4 Exact Mass: 396.1798 Molecular Weight: 396.447 Elemental Analysis: C, 63.62; H, 6.10; N, 14.13; O, 16.14 |
Technical Information |
Synonym: SKLB-23bb; 23bb; SKLB 23bb Chemical Name: Butanamide, N-hydroxy-4-[2-methoxy-5-[methyl(2-methyl-4-quinazolinyl)amino]phenoxy]- InChi Key: FWXZZFONXWYSEF-UHFFFAOYSA-N InChi Code: InChI=1S/C21H24N4O4/c1-14-22-17-8-5-4-7-16(17)21(23-14)25(2)15-10-11-18(28-3)19(13-15)29-12-6-9-20(26)24-27/h4-5, 7-8, 10-11, 13, 27H, 6, 9, 12H2, 1-3H3, (H, 24, 26) SMILES Code: O=C(NO)CCCOC1=CC(N(C)C2=C3C=CC=CC3=NC(C)=N2)=CC=C1OC |