Rottlerin (Mallotoxin; NSC 56346; NSC 94525)

InvivoChem Cat #:V5106CAS #:82-08-6Purity >=98%

Description: Rottlerin (NSC-56346; NSC-94525), a naturally occuring compound isolated from Mallotus Philippinensis with the potential to be used as a chemotherapeutic agent for adrenocortical carcinoma, is a novel and specific protein kinase C (PKC) inhibitor with IC50 values for PKCdelta of 3-6 uM, PKCalpha, beta, gamma of 30-42 uM, PKCepsilon, eta, zeta of 80-100 uM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation. Rottlerin is an angiogenesis inhibitor and an inhibitor of protein kinase Cdelta (PKCdelta) and calmodulin kinase III.

References: Cancer Letters 353 (2014) 32-40.

-20C for 3 years in powder form

Synonym: Mallotoxin; NSC 56346; NSC 94525; NSC56346; NSC94525; Kamalin; NSC-56346; NSC-94525.
Chemical Name: (E)-1-(6-((3-Acetyl-2, 4, 6-trihydroxy-5-methylphenyl)methyl)-5, 7-dihydroxy-2, 2-dimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one
InChi Key: DEZFNHCVIZBHBI-ZHACJKMWSA-N
InChi Code: InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3, 4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13, 33-37H, 14H2, 1-4H3/b11-10+
SMILES Code: CC1(C)C=CC2=C(O)C(CC3=C(C(C)=C(C(C(C)=O)=C3O)O)O)=C(O)C(C(/C=C/C4=CC=CC=C4)=O)=C2O1