InvivoChem Cat #:V5077CAS #:299-75-2Purity >=98%Description: Treosulfan (NSC 39069; Treosulphan) is a novel and potent DNA alkylating agent with activity in ovarian cancer and other solid tumor types. Treosulfan is the product of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppresive, and antineoplastic activities. Under physiological conditions, treosulfan converts nonenzymatically to L-diepoxybutane via a monoepoxide intermediate. The monoepoxide intermediate and L-diepoxybutane alkylate DNA at guanine residues and produce DNA interstrand crosslinks, resulting in DNA fragmentation and apoptosis. In escalated doses, this agent also exhbits myeloablative and immunosuppressive activities.
References: Anticancer Res. 2014 Apr; 34(4):1779-84.
Related CAS #: 299-75-2 (Treosulfan); 55-98-1 (Busulfan); 52-24-4 (Thiotepa, Girostan; AI3-24916; NSC-6396)