mitoquinone-mesylate

InvivoChem Cat #:V4979CAS #:845959-50-4 (mesylate)Purity >=98%

Description: Mitoquinone mesylate (also known as MITOQ; MitoQ or MitoQ10) is a novel and potent TPP-based, mitochondrially targeted antioxidant designed to accumulate within mitochondria in vivo in order to protect against oxidative damage. MitoQ comprises a positively charged lipophilic cation that drives its extensive accumulation within the negatively charged mitochondria inside cells. The active antioxidant component of MitoQ is ubiquinone, which is identical to the active antioxidant in Coenzyme Q10. It is this approximately thousand-fold greater concentration of MitoQ within mitochondria that makes it more effective at preventing mitochondrial oxidative damage when compared to untargeted antioxidants such as Coenzyme Q10. NOTE: For the convenience of use, this product is supplied as 200mg /mL solution in ethanol-water (1:1, v/v) solution since pure MitoQ10 is a tar-like or waxy semi-solid and very hard to transfer between containers.

References: J Pharmacol Exp Ther. 2011 Mar; 336(3):682-92.; Mediators Inflamm. 2015; 2015:901780.

Related CAS #: 845959-50-4 (mesylate); 845959-52-6 (beta-CD complex); 444890-41-9 (cation); 336184-91-9 (bromide)

-20C for 3 years in powder form

Synonym: Mitoquinone methanesulfonate; MitoQ10 mesylate; MitoQ mesylate; MitoQ; Mito Q10; MitoQ10; MitoQ-10;
IUPAC/Chemical Name: (10-(4, 5-dimethoxy-2-methyl-3, 6-dioxocyclohexa-1, 4-dien-1-yl)decyl)triphenylphosphonium methanesulfonate
InChi Key: GVZFUVXPTPGOQT-UHFFFAOYSA-M
InChi Code: InChI=1S/C37H44O4P.CH4O3S/c1-29-33(35(39)37(41-3)36(40-2)34(29)38)27-19-8-6-4-5-7-9-20-28-42(30-21-13-10-14-22-30, 31-23-15-11-16-24-31)32-25-17-12-18-26-32; 1-5(2, 3)4/h10-18, 21-26H, 4-9, 19-20, 27-28H2, 1-3H3; 1H3, (H, 2, 3, 4)/q+1; /p-1
SMILES Code: O=C(C(CCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=C4C)C(OC)=C(OC)C4=O.CS(=O)([O-])=O