Description |
InvivoChem Cat #:V4975CAS #:98185-20-7 (tartrate)Purity >=98%Description: Raclopride (formerly also known as FLA 870) is a novel, potent and selective dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively. Raclopride's selectivity to the cerebral D2 receptors is characterized by its respective Ki-values, which are as follows: 1.8, 3.5, 2400 and 18000 nM for D2, D3, D4 and D1 receptors respectively. It can be radiolabelled with radioisotopes, e.g. 3H or 11C and used as a tracer for in vitro imaging (autoradiography) as well as in vivo imaging positron emission tomography (PET). Images obtained by cerebral PET scanning (e.g. PET/CT or PET/MRI) allow the non-invasive assessment of the binding capacity of the cerebral D2 dopamine receptor, which can be useful for the diagnosis of movement disorders. References: Trends Pharmacol Sci. 1994 Jul; 15(7):264-70. Related CAS #: 98185-20-7 (tartrate); 84225-95-6 (free base) |
![Raclopride tartrate]()
|
Name: Raclopride tartrate CAS#: 98185-20-7 (tartrate) Chemical Formula: C19H26Cl2N2O9 Exact Mass: 496.1015 Molecular Weight: 497.322 Elemental Analysis: C, 45.89; H, 5.27; Cl, 14.26; N, 5.63; O, 28.95 |
Technical Information |
Synonym: Raclopride; FLA 870; FLA-870; FLA870; IUPAC/Chemical Name: (S)-3, 5-dichloro-N-((1-ethylpyrrolidin-2-yl)methyl)-2-hydroxy-6-methoxybenzamide (2R, 3R)-2, 3-dihydroxysuccinate InChi Key: QULBVRZTKPQGCR-NDAAPVSOSA-N InChi Code: InChI=1S/C15H20Cl2N2O3.C4H6O6/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2; 5-1(3(7)8)2(6)4(9)10/h7, 9, 20H, 3-6, 8H2, 1-2H3, (H, 18, 21); 1-2, 5-6H, (H, 7, 8)(H, 9, 10)/t9-; 1-, 2-/m01/s1 SMILES Code: O=C(NC[CH]1N(CC)CCC1)C2=C(OC)C(Cl)=CC(Cl)=C2O.O=C(O)[CH](O)[CH](O)C(O)=O |