gw-870086

InvivoChem Cat #:V4929CAS #:827319-43-7Purity >=98%

Description: GW-870086 is a novel and potent glucocorticoid receptor agonist that has anti-inflammatory properties, and thus can be potentially usef for the treatment of asthma and atopic dermatitis.. It acts as a glucocorticoid receptor agonist with a pIC50 of 10.1 in A549 cells expressing NF-kappaB.

References: Br J Pharmacol. 2013 Jul; 169(6):1389-403.; Invest Ophthalmol Vis Sci. 2013 Mar 1; 54(3):2100-7.

-20C for 3 years in powder form

Synonym: GW-870086; GW-870086X; 870086; GW870086; GW870086X; GW 870086; GW 870086X
IUPAC/Chemical Name: Androsta-1, 4-diene-17-carboxylic acid, 6, 9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(((2, 2, 3, 3-tetramethylcyclopropyl)carbonyl)oxy)-, cyanomethyl ester, (6alpha, 11beta, 16alpha, 17alpha)-
InChi Key: WUBKGTSFJSEIEM-NSHBDUGJSA-N
InChi Code: InChI=1S/C31H39F2NO6/c1-16-12-18-19-14-21(32)20-13-17(35)8-9-28(20, 6)30(19, 33)22(36)15-29(18, 7)31(16, 25(38)39-11-10-34)40-24(37)23-26(2, 3)27(23, 4)5/h8-9, 13, 16, 18-19, 21-23, 36H, 11-12, 14-15H2, 1-7H3/t16-, 18+, 19+, 21+, 22+, 28+, 29+, 30+, 31+/m1/s1
SMILES Code: C[C]12[C](C(OCC#N)=O)(OC(C3C(C)(C)C3(C)C)=O)[CH](C)C[C]1([H])[C]4([H])C[CH](F)C5=CC(C=C[C]5(C)[C]4(F)[CH](O)C2)=O