ly2812223

InvivoChem Cat #: V4857CAS #:1311385-20-2Purity >=98%

Description: LY2812223 is a novel, highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity (Ki) of 144 nM and 156 nM for mGlu2 and mGlu3, respectively. Identification of orthosteric mGlu(2/3) receptor agonists capable of discriminating between individual mGlu2 and mGlu3 subtypes has been highly challenging owing to the glutamate-site sequence homology between these proteins. Evaluation of LY2812223 in a rat model responsive to mGlu2 receptor activation coupled with a measure of central drug disposition provides evidence that this molecule engages and activates central mGlu2 receptors in vivo.

References: J Med Chem. 2015 Sep 24; 58(18):7526-48.

-20C for 3 years in powder form

Synonym: LY-2812223; LY 2812223; LY2812223
IUPAC/Chemical Name: (1S, 2S, 4R, 5R, 6S)-2-Amino-4-methylbicyclo[3.1.0]hexane2, 6-dicarboxylic acidLY-2812223; (1R, 2S, 4R, 5R, 6R)-2-Amino-4-(1H-1, 2, 4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2, 6-dicarboxylic acid
InChi Key: YSOWRGMLMZQSBX-AVUIYAGVSA-N
InChi Code: InChI=1S/C10H12N4O4S/c11-10(8(17)18)1-3(19-9-12-2-13-14-9)4-5(6(4)10)7(15)16/h2-6H, 1, 11H2, (H, 15, 16)(H, 17, 18)(H, 12, 13, 14)/t3-, 4+, 5+, 6+, 10+/m1/s1
SMILES Code: [H][C]12[C]([CH]2C(O)=O)([H])[C](C(O)=O)(N)C[CH]1SC3=NNC=N3