Vergleich

pf-06747711

ArtNr V4466-100mg
Hersteller InvivoChem LLC
CAS-Nr. 1892576-58-7
Menge 100mg
Kategorie
Typ Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Lieferbar
Description
InvivoChem Cat #:V4466CAS #:1892576-58-7 Purity >=98%

Description: PF-06747711 is a novel, potent, selective, and orally bioactive retinoic acid receptor-related orphan C2 (RORC2, also known as RORgammat) inverse agonist, with an IC50 of 4.1 nM. It was identified from a high-throughput screening and displayed promising binding affinity for RORC2, inhibition of IL-17 production in Th17 cells, and selectivity against the related RORA and RORB receptor isoforms. Lead optimization to improve the potency and metabolic stability of this hit focused on two key design strategies, namely, iterative optimization driven by increasing lipophilic efficiency and structure-guided conformational restriction to achieve optimal ground state energetics and maximize receptor residence time. This approach successfully identified PF-06747711 as a potent and selective RORC2 inverse agonist, demonstrating good metabolic stability, oral bioavailability, and the ability to reduce IL-17 levels and skin inflammation in a preclinical in vivo animal model upon oral administration. Anti-skin inflammatory activity. The nuclear hormone receptor retinoic acid receptor-related orphan C2 (RORC2, also known as RORgammat) is a promising target for the treatment of autoimmune diseases. A small molecule, inverse agonist of the receptor is anticipated to reduce production of IL-17, a key proinflammatory cytokine.

References: 2018 Dec 13; 61(23):10415-10439.


PF-06747711

Name: PF-06747711
CAS#: 1892576-58-7
Chemical Formula: C26H26F3N5O2
Exact Mass: 497.2039
Molecular Weight: 497.5222
Elemental Analysis: C, 62.77; H, 5.27; F, 11.46; N, 14.08; O, 6.43
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Technical Information
Synonym: PF-06747711; PF 06747711; PF06747711
IUPAC/Chemical Name: 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2, 3-b]pyridin-5-yl)benzamide
InChi Key: BIHPJIJLDNUDGH-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H26F3N5O2/c1-15(2)25(36)34-9-7-17(8-10-34)19-14-33(3)23-21(19)22(26(27, 28)29)20(13-31-23)32-24(35)18-6-4-5-16(11-18)12-30/h4-6, 11, 13-15, 17H, 7-10H2, 1-3H3, (H, 32, 35)
SMILES Code: O=C(NC1=CN=C(N(C)C=C2C3CCN(C(C(C)C)=O)CC3)C2=C1C(F)(F)F)C4=CC=CC(C#N)=C4

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100mg
Lieferbar: In stock
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