azd-5904

Description: AZD5904 is a novel, potent, orally bioavailable, irreversible inhibitor of human MPO (Myeloperoxidase) with an IC50 of 140 nM and with similar potency in mouse and rat. It is 10 to 19-fold selective compared to the closely related lactoperoxidase and thyroid peroxidase; it shows > 70-fold selectivity over a broad panel of other enzymes, ion channels, and receptors. In isolated human neutrophils, 1 uM inhibited PMA stimulated HOCl by > 90%. In rats, a plasma concentration of ca.5 uM decreased the in vivo formation of glutathione sulphonamide (a product of the reaction of HOCl with glutathione) from in situ zymosan activated peritoneum neutrophils.

References: Myeloperoxidase (MPO) inhibitor.