hibifolin

Description: Hibifolin is a novel and potent flavonol glycoside derived from herbal plants, it possessed a strong protective activity against cell death induced by aggregated Abeta. Application of hibifolin in primary cortical neurons prevented the Abeta-induced cell death in a dose-dependent manner. In cultured cortical neurons, the pre-treatment of hibifolin abolished Abeta-induced Ca2+ mobilization, and also reduced Abeta-induced caspase-3 and caspase-7 activation. Moreover, DNA fragmentation induced by Abeta could be suppressed by hibifolin. In addition to such protection mechanisms, hibifolin was able to induce Akt phosphorylation in cortical neurons, which could be another explanation for the neuroprotection activity. These results therefore provided the first evidence that hibifolin protected neurons against Abeta-induced apoptosis and stimulated Akt activation, which would be useful in developing potential drugs or food supplements for treating AD.

References: Neuroscience Letters, Volume 461, Issue 2, 11 September 2009, Pages 172-176.