Description |
InvivoChem Cat #:V4194CAS #:794568-90-4 Purity >=98%Description: BAY 73-6691 racemate is a novel, potent, selective, and brain penetrant PDE9A (Phosphodiesterase 9) inhibitor. Alzheimer's disease (AD) is accompanied by enhanced oxidative stress and excess free radicals. BAY 73-6691 may attenuate the oxidative stress during the development of AD is still unclear. For this purpose, primary cultures of SH-SY5Y cells were incubated with 20uM beta-amyloid25-35 (Abeta25-35), followed by exposure to different concentrations (50, 100, 150 and 200ug/ml) of BAY 73-6691. Furthermore, the antioxidant effect of BAY 73-6691 was evaluated in mice subjected to intracerebroventricular injection of Abeta25-35 (day 0) and treatment with BAY 73-6691 by intraperitoneal injection once daily (days 1-10). Our results elucidated that treatment with BAY 73-6691 attenuated the Abeta25-35-induced cytotoxicity and oxidative stress in SH-SY5Y cells. In vivo, BAY 73-6691 protected Abeta25-35-induced oxidative damage in hippocampus, associated with the attenuation of impairments in hippocampal neurons. Administration of BAY 73-6691 improved learning and memory in the Morris water maze test, and restored several hippocampal memory-associated proteins. This study identified a neuroprotective role for BAY 73-6691 against Abeta25-35-induced oxidative stress in vivo and in vitro, harboring therapeutic potential for the treatment of AD by alleviating the impairments in spatial memory and hippocampal neurons. Description: References: Brain Res. 2016 Jul 1; 1642:327-335. References:Related CAS#:794568-92-6 (R)-BAY 73-6691 |
![BAY 73-6691 racemate](/Private/g3/M00/03/F9/CgAH51223rSAet_uAAAqiZONaa8833.png) |
Name: BAY 73-6691 racemate CAS#: 794568-90-4 (racemate) Chemical Formula: C15H12ClF3N4O Exact Mass: 356.06517 Molecular Weight: 356.73 Elemental Analysis: C, 50.50; H, 3.39; Cl, 9.94; F, 15.98; N, 15.71; O, 4.49 |
Technical Information |
Synonym: BAY 73-6691 racemate; BAY736691; BAY73-6691; UNII-80ZTV3INTW; (R)-Bay-73-6691; IUPAC/Chemical Name: 4H-Pyrazolo(3, 4-d)pyrimidin-4-one, 1-(2-chlorophenyl)-1, 5-dihydro-6-((2R)-3, 3, 3-trifluoro-2-methylpropyl)- InChi Key: FFPXPXOAFQCNBS-MRVPVSSYSA-N InChi Code: InChI=1S/C15H12ClF3N4O/c1-8(15(17, 18)19)6-12-21-13-9(14(24)22-12)7-20-23(13)11-5-3-2-4-10(11)16/h2-5, 7-8H, 6H2, 1H3, (H, 21, 22, 24)/t8-/m1/s1 SMILES Code: C[CH](Cc1[nH]c(=O)c2cnn(c2n1)c3ccccc3Cl)C(F)(F)F |