motesanib

Description: Motesanib (formerly also known as AMG-706) is a novel, potent, ATP-competitive, orally bioavailable inhibitor of VEGFR1/2/3 (vascularendothelial growth factor) with IC50 of 2 nM/3 nM/6 nM, respectively; ithas potential anticancer activity; Motesanib shows similar activityagainst Kit, and ca.10-fold more selective for VEGFR than PDGFR and Ret.Motesanib selectively targets and inhibits VEGFR, PDGFR, kit, and Retreceptors, thereby inhibiting angiogenesis and cellular proliferation.

References: Cancer Res. 2006; 66(17):8715-21; Clin Cancer Res. 2010; 16(14):3639-47; Clin Cancer Res. 2009; 15(1):110-8.

Related CAS: 453562-69-1 (free base); 57876-30-3 (phosphate)

Chemical Name: N-(3, 3-dimethyl-2, 3-dihydro-1H-indol-6-yl)-2-[(pyridin-4- ylmethyl)amino]pyridine-3-carboxamide

InChi Key: RAHBGWKEPAQNFF-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12, 26H, 13-14H2, 1-2H3, (H, 24, 25)(H, 27, 28)

SMILES Code: O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC4=C(C=C3)C(C)(C)CN4