coluracetam

Description: Coluracetam (also known as MKC-231 and BCI-540) is a novel choline uptake enhancer. MKC-231(10(-10)-10(-6) moll) significantly increased high affinity choline uptake (HACU) when it was incubated with the hippocampal synaptosomes of ethylcholine mustard aziridinium ion (AF64A) treated rats, but not of normal rats. MKC-231 did not affect the AChE activity, 3H- quinuclidinyl benzilate binding, and 3H-pirenzepine binding. Oral administration of MKC-231 (1-10 mg/kg) significantly improved the learning deficits in the Morris' water maze of AF64A-treated rats, but it did not produce any significant side effects, like tremor, salivation or hypothermia, which were observed in rats treated with high doses of tacrine.

References: Arzneimittelforschung. 1996 Apr; 46(4):369-73.